DescriptionHelp Knight conquer an ancient evil in this epic puzzle RPG, set in a world of monsters, treasure and adventure!InstructionsYou must guide Knight around the board through a combination of destroying block groups and rotating the entire play area, grabbing the key for the exit as you go. Rotate the board by clicking the arrows on either side of it, or by using the left and right arrow keys.
To clear a group of blocks, just click the group to highlight them then click again to destroy them.This time round, you are able to destroy 2 or 1-block groups as well as the usual 3 or above, but at an increased cost to your Action Points, which decrease each time you make a move. Lastly, land on enemies and objects to kill or collect them, but choose your battles wisely! If you need a rest, you can also use 'P' or 'SPACE' to pause the game.Related GamesPlays: 1043762Ratings: 738Plays: 519416Ratings: 1298Plays: 655302Ratings: 1537.
Learn to Fly 2. Learn to Fly 3. Learn To Fly Idle. Lee Lee's Quest 2. Legend of the Golden Robot. Legend Of Zelda. Lemonade Stand. Lemonade World. Let's go Jaywalking. Line Rider 2. Linebacker 2. Linebacker Alley. Linebacker Alley 2. Love Calculator. Learn to Fly Instructions. One Penguin Takes it personally when he is surfing the web and stumbles upon a web site telling him that he cant fly, after that he sets his mind to research and practice flying until he can prove the world that he can.
The flight engineer on an Avro Lancaster checks settings on the control panel from his seat in the cockpit
A flight engineer (FE), also sometimes called an air engineer, is the member of an aircraft's flight crew who monitors and operates its complex aircraft systems. In the early era of aviation, the position was sometimes referred to as the 'air mechanic'. Flight engineers can still be found on some larger fixed-wingairplanes, and helicopters. A similar crew position exists on some spacecraft. In most modern aircraft, their complex systems are both monitored and adjusted by electronic microprocessors and computers, resulting in the elimination of the flight engineer's position.
In earlier days, most larger aircraft were designed and built with a flight engineer's position. For U.S. civilian aircraft that require a flight engineer as part of the crew, the FE must possess an FAA Flight Engineer Certificate with reciprocating, turboprop, or turbojet ratings appropriate to the aircraft. Whereas the four-engine Douglas DC-4 did not require an FE, the FAA type certificates of subsequent four-engine reciprocating engine airplanes (DC-6, DC-7, Constellation, Boeing 307 and 377) and early three- and four-engine jets (Boeing 707, 727, early 747, DC-8, DC-10, L-1011) required flight engineers. Later three- and four-engine jets (MD-11, 747-400, and later) were designed with sufficient automation to eliminate the position.
History[edit]
Historically, as airplanes became ever larger, requiring more engines and complex systems to operate, the workload on two pilots became excessive during certain critical parts of the flight regimes, particularly takeoffs and landings. Piston engines on an airplane required a great deal of attention throughout the flight with their multitude of gauges and indicators. Inattention or a missed indication could result in engine or propeller failure, and quite possibly cause the loss of the aircraft if prompt corrective action was not taken.
In order to dedicate a person to monitoring the aircraft's engines and its other critical flight systems, the position of 'flight engineer' (FE) was created. The FE did not actually fly the airplane; instead, the FE's position had a specialized control panel allowing for the monitoring and control of various aircraft systems. The FE is therefore an integrated member of the flight deck crew who works in close coordination with the two pilots during all phases of flight.
Traditionally, the FE station has been usually placed on the main flight deck just aft of the pilot and copilot, and close to the navigator. Earlier referred to as a 'flight mechanic' on the four-engine commercial seaplanes like the Sikorsky S-42, Martin M-130 and the Boeing 314 Clipper, the FE's role was referred to as an 'engineer' (much like a ship's engineer) on the first very large flying boat, the Dornier Do X. On the Do X the FE operated a large and complex engineering station similar to later large transport aircraft to monitor the twelve engines.
The first US military aircraft to include a FE was the Consolidated PBY which was introduced into naval service in 1936. The FE panel was located in the pylon between the fuselage and the wing. The FE did not have ignition, throttle and propeller controls, thus a person in the cockpit was also required to start the engines.[1]
The first commercial land airplane to include a flight engineering station was the Boeing 307 Stratoliner, but only ten were built before the onset of World War II. During the war the Avro Lancaster and Handley Page Halifaxbombers employed FEs, as these large aircraft employed only a single pilot. The first Allied military operation during the Second World War involving FEs occurred in February 1941 with a Short Stirling; it was the first four-engined bomber-raid of the war by the RAF.[2]
Duties[edit]
The cockpit of a non-operational four-engine Ilyushin Il-86, with its flight engineer's station at right
The flight engineer ('air engineer' in the Royal Air Force) is primarily concerned with the operation and monitoring of all aircraft systems,[3] and is required to diagnose, and where possible rectify or eliminate, any faults that may arise. On most multi-engine airplanes, the FE sets and adjusts engine power during takeoff, climb, cruise, go-arounds, or at any time the pilot flying requests a specific power setting to be set during the approach phase. The FE sets and monitors major systems,[4] including fuel, pressurization and air conditioning, hydraulic, electrics (engine driven generators, auxiliary power units), gas turbine compressor/air turbine motor (APU, GTC, ATM), ice and rain protection (engine and nacelle anti-ice, window heat, probe heater), oxygen, fire and overheat protection of all systems, liquid cooling system (Boeing E-3), draw through cooling system (Boeing E-3), forced air cooling system (Boeing E-3), and powered flying controls.
FEs are also responsible for preflight and postflight aircraft inspections, and ensuring that the weight and balance of the aircraft is correctly calculated to ensure the centre of gravity is within limits.[4] On airplanes where the FE's station is located on the same flight deck just aft of the two pilots (all western three- and four-man deck airplanes), they also monitor an aircraft's flight path, speed, and altitude. A significant portion of their time is spent cross checking pilot selections. The FE is the systems expert of the airplane with an extensive mechanical and technical knowledge of aircraft systems and aircraft performance.[4] On some military airplanes (Lockheed C-5 Galaxy, Boeing E-3 Sentry, McDonnell Douglas KC-10) the FE sits behind the co-pilot in the cockpit, facing outboard to operate a panel of switches, gauges and indicators or forward to operate throttles, lighting controls, flight controls. On the Tupolev Tu-134 the FE sits in the nose of the aircraft. On other western military airplanes, such as on the Lockheed P-3 Orion and Lockheed C-130H Hercules, FEs sit between, slightly aft of (and, in the case of the C-130A-H models, slightly higher than) the pilots. On the P-3 Orion and E-3 Sentry the FE is responsible for starting and shutting down engines at the start and end of each flight, and also during in-flight shutdowns which are carried out to save fuel on long range operations. In some militaries, the aircraft's FE is also authorised to make and certify repairs to the aircraft when it is away from its base. This can eliminate the need for technical repair crews to accompany the aircraft on short deployments.
On civilian airplanes the FE is positioned so that he or she can monitor the forward instruments, pilot selections and adjust the thrust levers located on the centre pedestal; the FE's chair can travel forward and aft and it can swivel laterally 90 degrees, which enables him or her to face forward and set the engine power, then move aft and rotate sideways to monitor and set the systems panel. The FE is the aircraft systems expert onboard and responsible for troubleshooting and suggesting solutions to in-flight emergencies and abnormal technical conditions, as well as computing takeoff and landing data. The FE's seat on modern aircraft has a complete range of motion (side to side, forward to aft, swivel, up and down) to accommodate the many positions required to monitor and operate the aircraft systems.
The basic philosophy of a three-person flight deck in many flight operations, should an abnormality or emergency arise, is for the captain to hand over the actual flying of the aircraft to the first officer (co-pilot). The captain and FE together review and carry out the necessary actions required to contain and rectify the problem. This spreads the workload and ensures a system of cross-checking which maximizes safety. The captain is the manager and decision maker (pilot not flying, PNF), the first officer, or co-pilot, is the actual flier of the aircraft (pilot flying, PF), and the FE reads the check-lists and executes actions required under the auspices of the captain. There can be occasions when the roles of the pilots during an emergency are reversed, i.e. the copilot becomes the PNF and the captain becomes the PF; one such example was on the A300 B-Series aircraft when there was a complete loss of generator-supplied electrical power, whereupon the standby instruments that were powered were on the captain's side only, requiring the captain to be PF and the PNF and FE to resolve the issue.
During World War II many U.S. bomber aircraft incorporated a flight engineer's position. However, this position also doubled as a gunner, usually operating the upper turret, as was the case of the Boeing B-17 Flying Fortress. On some commercial airliners with a flight engineer, the FE is the third in command, after the captain and first officer.
Elimination[edit]
Starting in the 1980s, the development of powerful and small integrated circuits and other advances in computers and digital technology eliminated the need for flight engineers on airliners and many modern military aircraft. Some of the last aircraft built with FE stations were early-production Boeing 767s, Tupolev Tu-154s, and military variants of the Boeing 707, such as the E-3 Sentry and E-6 Mercury.
On two-pilot flight deck airplanes, sensors and computers monitor and adjust systems automatically.[3] There is no onboard technical expert and third pair of eyes. If a malfunction, abnormality or emergency occurs, it is displayed on an electronic display panel and the computer automatically initiates corrective action to rectify the abnormal condition. One pilot does the flying and the other pilot resolves the issue. Modern technological advancements in today's aircraft have reduced the dependence upon human control over systems.[3]
See also[edit]
References[edit]
Look up flight engineer in Wiktionary, the free dictionary. |
- ^US Navy. Pilot's Handbook Model PBY-5 Flying Boat
- ^Stringman, D.C. (Flt. Lt.). The History of the Air Engineer: Training in the Royal Air Force, U.K.: RAF Finningley, 1984, pp. 39–43.
- ^ abcCox, John. Ask the Captain: What does the flight engineer do?, USA Today, March 23, 2014. Retrieved August 14, 2014.
- ^ abcEldridge, Andrea. Confessions of a Flight Engineer: Flashlights, timers, and breath mints required, Air & Space Smithsonian magazine, November 2011.
5-lipoxygenase-activating proteinArachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene.
ALOX5AP
Available structuresPDB Ortholog search: PDBe RCSBList of PDB id codes2Q7R, 2Q7M
IdentifiersAliases ALOX5AP, FLAP, arachidonate 5-lipoxygenase activating proteinExternal IDs OMIM: 603700 MGI: 107505 HomoloGene: 1231 GeneCards: ALOX5APGene location (Human)
Chr. Chromosome 13 (human)
Band 13q12.3 Start 30,713,478 bpEnd 30,764,426 bpGene location (Mouse)
Chr. Chromosome 5 (mouse)
Band 5|5 G3 Start 149,264,767 bpEnd 149,288,153 bpRNA expression pattern
More reference expression dataGene ontologyMolecular function • glutathione transferase activity• protein N-terminus binding• leukotriene-C4 synthase activity• glutathione peroxidase activity• protein binding• arachidonic acid binding• enzyme activator activityCellular component • integral component of membrane• nuclear membrane• endoplasmic reticulum membrane• membrane• nuclear envelope• endoplasmic reticulum• cell nucleusBiological process • cellular response to calcium ion• leukotriene metabolic process• positive regulation of catalytic activity• protein homotrimerization• lipoxygenase pathway• leukotriene biosynthetic process• lipoxin metabolic process• cellular oxidant detoxification• lipoxin biosynthetic processSources:Amigo / QuickGOOrthologsSpecies Human MouseEntrez 241
11690
Ensembl ENSG00000132965
ENSMUSG00000060063
UniProt P20292
P30355
RefSeq (mRNA) NM_001204406NM_001629
NM_009663NM_001308462
RefSeq (protein) NP_001191335NP_001620
NP_001295391NP_033793
Location (UCSC) Chr 13: 30.71 – 30.76 Mb Chr 5: 149.26 – 149.29 MbPubMed search WikidataView/Edit Human View/Edit MouseFunctionFLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes, 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and specialized pro-resolving mediators of the lipoxin and resolvin classes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. FLAP structure consist of 4 transmembrane alpha helices, but they are found in 3’s( trimer) forming a barrel. The barrel is about 60 A high and 36 A wide.
Clinical significanceLeukotrienes, which need the FLAP protein to be made, have an established pathological role in allergic and respiratory diseases. Animal and human genetic evidence suggests they may also have an important role in atherosclerosis, myocardial infarction, and stroke. The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis.
InhibitorsAM-6795-lipoxygenase-activating proteinArachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene.
ALOX5AP
Available structuresPDB Ortholog search: PDBe RCSBList of PDB id codes2Q7R, 2Q7M
IdentifiersAliases ALOX5AP, FLAP, arachidonate 5-lipoxygenase activating proteinExternal IDs OMIM: 603700 MGI: 107505 HomoloGene: 1231 GeneCards: ALOX5APGene location (Human)
Chr. Chromosome 13 (human)
Band 13q12.3 Start 30,713,478 bpEnd 30,764,426 bpGene location (Mouse)
Chr. Chromosome 5 (mouse)
Band 5|5 G3 Start 149,264,767 bpEnd 149,288,153 bpRNA expression pattern
More reference expression dataGene ontologyMolecular function • glutathione transferase activity• protein N-terminus binding• leukotriene-C4 synthase activity• glutathione peroxidase activity• protein binding• arachidonic acid binding• enzyme activator activityCellular component • integral component of membrane• nuclear membrane• endoplasmic reticulum membrane• membrane• nuclear envelope• endoplasmic reticulum• cell nucleusBiological process • cellular response to calcium ion• leukotriene metabolic process• positive regulation of catalytic activity• protein homotrimerization• lipoxygenase pathway• leukotriene biosynthetic process• lipoxin metabolic process• cellular oxidant detoxification• lipoxin biosynthetic processSources:Amigo / QuickGOOrthologsSpecies Human MouseEntrez 241
11690
Ensembl ENSG00000132965
ENSMUSG00000060063
UniProt P20292
P30355
RefSeq (mRNA) NM_001204406NM_001629
NM_009663NM_001308462
RefSeq (protein) NP_001191335NP_001620
NP_001295391NP_033793
Location (UCSC) Chr 13: 30.71 – 30.76 Mb Chr 5: 149.26 – 149.29 MbPubMed search WikidataView/Edit Human View/Edit MouseFunctionFLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes, 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and specialized pro-resolving mediators of the lipoxin and resolvin classes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. FLAP structure consist of 4 transmembrane alpha helices, but they are found in 3’s( trimer) forming a barrel. The barrel is about 60 A high and 36 A wide.
Clinical significanceLeukotrienes, which need the FLAP protein to be made, have an established pathological role in allergic and respiratory diseases. Animal and human genetic evidence suggests they may also have an important role in atherosclerosis, myocardial infarction, and stroke. The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis.
InhibitorsAM-6795-lipoxygenase-activating proteinArachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene.
ALOX5AP
Available structuresPDB Ortholog search: PDBe RCSBList of PDB id codes2Q7R, 2Q7M
IdentifiersAliases ALOX5AP, FLAP, arachidonate 5-lipoxygenase activating proteinExternal IDs OMIM: 603700 MGI: 107505 HomoloGene: 1231 GeneCards: ALOX5APGene location (Human)
Chr. Chromosome 13 (human)
Band 13q12.3 Start 30,713,478 bpEnd 30,764,426 bpGene location (Mouse)
Chr. Chromosome 5 (mouse)
Band 5|5 G3 Start 149,264,767 bpEnd 149,288,153 bpRNA expression pattern
More reference expression dataGene ontologyMolecular function • glutathione transferase activity• protein N-terminus binding• leukotriene-C4 synthase activity• glutathione peroxidase activity• protein binding• arachidonic acid binding• enzyme activator activityCellular component • integral component of membrane• nuclear membrane• endoplasmic reticulum membrane• membrane• nuclear envelope• endoplasmic reticulum• cell nucleusBiological process • cellular response to calcium ion• leukotriene metabolic process• positive regulation of catalytic activity• protein homotrimerization• lipoxygenase pathway• leukotriene biosynthetic process• lipoxin metabolic process• cellular oxidant detoxification• lipoxin biosynthetic processSources:Amigo / QuickGOOrthologsSpecies Human MouseEntrez 241
11690
Ensembl ENSG00000132965
ENSMUSG00000060063
UniProt P20292
P30355
RefSeq (mRNA) NM_001204406NM_001629
NM_009663NM_001308462
RefSeq (protein) NP_001191335NP_001620
NP_001295391NP_033793
Location (UCSC) Chr 13: 30.71 – 30.76 Mb Chr 5: 149.26 – 149.29 MbPubMed search WikidataView/Edit Human View/Edit MouseFunctionFLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes, 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and specialized pro-resolving mediators of the lipoxin and resolvin classes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. FLAP structure consist of 4 transmembrane alpha helices, but they are found in 3’s( trimer) forming a barrel. The barrel is about 60 A high and 36 A wide.
Clinical significanceLeukotrienes, which need the FLAP protein to be made, have an established pathological role in allergic and respiratory diseases. Animal and human genetic evidence suggests they may also have an important role in atherosclerosis, myocardial infarction, and stroke. The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis.
InhibitorsAM-679
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